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About Differin® (adapalene) Gel, 0.3%

Differin® Gel, 0.3%—a powerful formulation for patients with comedonal acne

Differin® Gel, 0.3% comes from the #1 topical retinoid brand prescribed by dermatologists.1 Galderma Laboratories developed Differin® Gel, 0.3% as a gel treatment formulation of the topical retinoid, adapalene. Differin® Gel, 0.3% is currently the most powerful formulation of Differin® available.

Differin® Gel, 0.3% is 3-mg/gram adapalene in a topical aqueous gel for use in the treatment of acne vulgaris in patients 12 years and older. Adapalene is a synthetic naphthoic acid derivative with retinoid activity. Topical retinoids are proven to treat comedonal lesions and help prevent the formation of microcomedones, the initial stage of all acne lesions.2 Biochemical and pharmacologic profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes, all of which represent important features in the pathology of acne vulgaris.

important safety info

Click here to learn about the indication and dosing for Differin® Gel, 0.3%. Learn More. Learn more about the powerful efficacy of Differin® Gel, 0.3% here. Learn More.

Important Safety Information

Differin® Gel, 0.3% and Differin® Lotion 0.1% are both indicated for the topical treatment of acne vulgaris in patients 12 years and older. Adverse events reported with use of Differin® products include skin dryness, erythema, scaling, stinging and burning. Most adverse events reported were mild to moderate in severity, occurred early in treatment and decreased thereafter. With use of Differin® Gel 0.3%, adverse events may also include general skin discomfort, pruritus and sunburn. Excessive exposure to sunlight and sunlamps should be avoided during treatment with all Differin® products, and use of sunscreen products and protective clothing is recommended. Concomitant use of drying or irritating topical products (like products containing resorcinol, salicylic acid or sulfur) should be used with caution. Instruct patients to avoid the eyes, lips and mucous membranes when applying Differin® products, and not to apply to areas that have been depilated with wax products. Differin® products have not been tested in pregnant or nursing women, or with the elderly. Both Differin® Gel, 0.3% and Differin® Lotion 0.1% are Pregnancy Category C. Please see full Prescribing Information for Differin Gel, 0.3% and please see full Prescribing Information for Differin Lotion, 0.1%.
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Important Safety Information

Differin® Gel, 0.3% and Differin® Lotion 0.1% are both indicated for the topical treatment of acne vulgaris in patients 12 years and older. Adverse events reported with use of Differin® products include skin dryness, erythema, scaling, stinging and burning. Most adverse events reported were mild to moderate in severity, occurred early in treatment and decreased thereafter. With use of Differin® Gel 0.3%, adverse events may also include general skin discomfort, pruritus and sunburn. Excessive exposure to sunlight and sunlamps should be avoided during treatment with all Differin® products, and use of sunscreen products and protective clothing is recommended. Concomitant use of drying or irritating topical products (like products containing resorcinol, salicylic acid or sulfur) should be used with caution. Instruct patients to avoid the eyes, lips and mucous membranes when applying Differin® products, and not to apply to areas that have been depilated with wax products. Differin® products have not been tested in pregnant or nursing women, or with the elderly. Both Differin® Gel, 0.3% and Differin® Lotion 0.1% are Pregnancy Category C. Please see full Prescribing Information for Differin Gel, 0.3% and please see full Prescribing Information for Differin Lotion, 0.1%.