Differin® (adapalene) Gel, 0.3% Frequently Asked Questions

What is Differin® Gel, 0.3%?
  • Differin® Gel, 0.3% is the most powerful form of Differin® for comedonal acne. It is 3-mg adapalene (a synthetic retinoid) in a topical aqueous gel for use in the treatment of acne vulgaris. For more information, please see full Prescribing Information.
What types of acne can Differin® Gel, 0.3% be used for?
  • Differin® Gel, 0.3% is indicated for use in patients 12 years and older with acne vulgaris. Differin® Gel, 0.3% treats acne and helps prevent the formation of the microcomedone—the precursor of all acne lesions—by acting as a modulator of cellular differentiation, anti-keratinization, and anti-inflammatory.2 Studies show that Differin® Gel, 0.3% is effective at treating comedonal acne.3
What is the difference between Differin® Gel, 0.3% and Differin® Lotion, 0.1%?
  • Differin® Gel, 0.3% is a clear retinoid gel with a powerful formulation for patients with comedonal acne. Differin® Lotion, 0.1% is new formulation of Differin® with a lower concentration of adapalene than Differin® Gel, 0.3%. It is the ONLY retinoid available in a lotion. Please see full Prescribing Information for Differin® Gel, 0.3% and Differin® Lotion, 0.1% to learn more.
What types of tolerability issues can I expect with my patients using Differin® Gel, 0.3%?
  • In a phase 3 study, the incidence of scaling, dryness, and stinging/burning was noted early in the study, but all signs and symptoms of skin irritation were transient in duration, peaking during the first weeks and decreasing over time3
  • Overexposure to sunlight or sunlamps—or extreme wind or cold—may increase the risk for irritation. When exposure can’t be avoided, patients should be instructed to use sunscreen or protective clothing. To learn more about the established tolerability profile of Differin® Gel, 0.3%, click here.
What time of day should I tell patients to use Differin® Gel, 0.3%?
  • Differin® Gel, 0.3% should be applied in the evening after washing with a nonmedicated soap. For more information on Differin® Gel, 0.3% dosing and application, please visit the Indication & Dosing page.
Are there any discounts or savings programs from which my patients can benefit?
  • Patients can register online at www.differin.com to download and print a Differin® Gel, 0.3% rebate coupon. With this printout, patients can receive a $35 rebate on their Differin® Gel, 0.3% prescription. With the $35 rebate and prescription insurance coverage, your patient’s Differin® 0.3% prescription could be free! Encourage your patients to use this rebate as it can be redeemed multiple times.
  • Click here to register and receive updates about other resources for your patients!

important safety info

Important Safety Information

Differin® Gel, 0.3% and Differin® Lotion 0.1% are both indicated for the topical treatment of acne vulgaris in patients 12 years and older. Adverse events reported with use of Differin® products include skin dryness, erythema, scaling, stinging and burning. Most adverse events reported were mild to moderate in severity, occurred early in treatment and decreased thereafter. With use of Differin® Gel 0.3%, adverse events may also include general skin discomfort, pruritus and sunburn. Excessive exposure to sunlight and sunlamps should be avoided during treatment with all Differin® products, and use of sunscreen products and protective clothing is recommended. Concomitant use of drying or irritating topical products (like products containing resorcinol, salicylic acid or sulfur) should be used with caution. Instruct patients to avoid the eyes, lips and mucous membranes when applying Differin® products, and not to apply to areas that have been depilated with wax products. Differin® products have not been tested in pregnant or nursing women, or with the elderly. Both Differin® Gel, 0.3% and Differin® Lotion 0.1% are Pregnancy Category C. Please see full Prescribing Information for Differin Gel, 0.3% and please see full Prescribing Information for Differin Lotion, 0.1%.
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Important Safety Information

Differin® Gel, 0.3% and Differin® Lotion 0.1% are both indicated for the topical treatment of acne vulgaris in patients 12 years and older. Adverse events reported with use of Differin® products include skin dryness, erythema, scaling, stinging and burning. Most adverse events reported were mild to moderate in severity, occurred early in treatment and decreased thereafter. With use of Differin® Gel 0.3%, adverse events may also include general skin discomfort, pruritus and sunburn. Excessive exposure to sunlight and sunlamps should be avoided during treatment with all Differin® products, and use of sunscreen products and protective clothing is recommended. Concomitant use of drying or irritating topical products (like products containing resorcinol, salicylic acid or sulfur) should be used with caution. Instruct patients to avoid the eyes, lips and mucous membranes when applying Differin® products, and not to apply to areas that have been depilated with wax products. Differin® products have not been tested in pregnant or nursing women, or with the elderly. Both Differin® Gel, 0.3% and Differin® Lotion 0.1% are Pregnancy Category C. Please see full Prescribing Information for Differin Gel, 0.3% and please see full Prescribing Information for Differin Lotion, 0.1%.