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Indication and Dosing Information for Differin® (adapalene) Gel, 0.3%

Indication

  • Differin® (adapalene) Gel, 0.3% is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older.

Dosing

  • Direct patients to apply a thin film of Differin® Gel, 0.3% to the entire face and any other affected areas of the skin once every evening after washing gently with a nonmedicated soap
  • Patients should avoid applying the gel treatment to the areas of skin around eyes, lips, and mucous membranes. A mild transitory sensation of warmth or slight stinging may occur shortly after the application of Differin® Gel, 0.3%
  • Patients should minimize sun exposure. Patients may be instructed to use noncomedogenic moisturizers for relief of dry skin or irritation; however, products containing alpha hydroxy or glycolic acids should be avoided
  • Exposure of the eye to this medication may result in reactions such as swelling, conjunctivitis, and eye irritation. This gel treatment should not be applied to cuts, abrasions, or eczematous or sunburned skin. Wax epilation should not be performed on treated skin due to the potential for skin erosions

Important Safety Information

Differin® Gel, 0.3% and Differin® Lotion 0.1% are both indicated for the topical treatment of acne vulgaris in patients 12 years and older. Adverse events reported with use of Differin® products include skin dryness, erythema, scaling, stinging and burning. Most adverse events reported were mild to moderate in severity, occurred early in treatment and decreased thereafter. With use of Differin® Gel 0.3%, adverse events may also include general skin discomfort, pruritus and sunburn. Excessive exposure to sunlight and sunlamps should be avoided during treatment with all Differin® products, and use of sunscreen products and protective clothing is recommended. Concomitant use of drying or irritating topical products (like products containing resorcinol, salicylic acid or sulfur) should be used with caution. Instruct patients to avoid the eyes, lips and mucous membranes when applying Differin® products, and not to apply to areas that have been depilated with wax products. Differin® products have not been tested in pregnant or nursing women, or with the elderly. Both Differin® Gel, 0.3% and Differin® Lotion 0.1% are Pregnancy Category C. Please see full Prescribing Information for Differin Gel, 0.3% and please see full Prescribing Information for Differin Lotion, 0.1%.
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Important Safety Information

Differin® Gel, 0.3% and Differin® Lotion 0.1% are both indicated for the topical treatment of acne vulgaris in patients 12 years and older. Adverse events reported with use of Differin® products include skin dryness, erythema, scaling, stinging and burning. Most adverse events reported were mild to moderate in severity, occurred early in treatment and decreased thereafter. With use of Differin® Gel 0.3%, adverse events may also include general skin discomfort, pruritus and sunburn. Excessive exposure to sunlight and sunlamps should be avoided during treatment with all Differin® products, and use of sunscreen products and protective clothing is recommended. Concomitant use of drying or irritating topical products (like products containing resorcinol, salicylic acid or sulfur) should be used with caution. Instruct patients to avoid the eyes, lips and mucous membranes when applying Differin® products, and not to apply to areas that have been depilated with wax products. Differin® products have not been tested in pregnant or nursing women, or with the elderly. Both Differin® Gel, 0.3% and Differin® Lotion 0.1% are Pregnancy Category C. Please see full Prescribing Information for Differin Gel, 0.3% and please see full Prescribing Information for Differin Lotion, 0.1%.